Since the TPA will be directly debiting my bank account, will I need to set up the TPA or ProfitStars as a new vendor in my Accounts Payable system?

Answer:

No, you do not need to set up a new vendor. This is because you are still making payments to the parties listed on your invoice – not to the TPA or Profit Stars. Once you select items for payment on the new portal, the debits are being executed by PNC Bank. PNC is acting as the Originating Depository Financial Institution (ODFI) in the ACH process on the TPA‘s behalf to route the payments to the Payees associated with the selected invoice line items.